PICOT is an acronym for the most important elements of a good clinical foreground question. It can also help guide the search strategy by identifying key concepts that need to be in the article to address the question.

Background questions ask for general knowledge or facts that are widely accepted about a condition and is normally addressed by textbooks, encyclopedias, or reviews. They are used to address basic information and not to make a clinical decision about a specific patient.
Foreground questions seek specific knowledge or evidence to inform clinical decisions. This evidence is typically found in journals and conference proceedings, and have several components that address a PICOT question.
| Patient/Population | Intervention | Comparison | Outcome | Time | |
| Question | Coma patients with traumatic brain injuries | Direct auditory stimulation (music) | Coma patients that receive non-direct auditory stimulation | Improved responsiveness on the Glasgow Coma Scale (GSC) | Over a 15 minute period |